Association between continuous use drugs and dizziness in institutionalized elderly people
Associação entre medicamentos de uso contínuo e tontura em idosos institucionalizados
Lidiane Maria de Brito Macedo Ferreira; Javier Jerez-Roig; Karyna Myrelly Oliveira Bezerra de Figueiredo Ribeiro; Francisca Sueli Monte Moreira; Kenio Costa de Lima
Abstract
Purpose: to associate continuous use drugs with the presence of dizziness in institutionalized elderly people.
Methods: a cross-sectional study performed in 10 nursing homes. People aged 60 years or older, able to walk and who presented good cognitive level were included in this study. Data on medications for continuous treatment and data referring to the Institution were collected. The elderly were asked if they had experienced dizziness in the previous year. The Chi-squared and Fisher exact tests were used for bivariate analysis and stepwise forward logistic regression to perform multiple analysis, with a significance level of 5%.
Results: out of 92 elderly, 35 reported dizziness in the previous year (23.8%). The anti-epileptics (p=0.034, RR=2.26, CI95% 1.06-4.78), antithrombotics (p=0.008, RR=0.21, CI95% 0.07-0.67) and diuretics (p=0.024, RR=2.29, CI95% 1.11-4.70) were associated to dizziness, adjusted by psycholeptics.
Conclusion: dizziness in these institutionalized elderly people was associated with the chronic use of anti-epileptics and diuretic drugs.
Keywords
Resumo
Objetivo: associar medicamentos de uso contínuo com a presença de tontura em idosos institucionalizados.
Métodos: trata-se de um estudo transversal realizado em 10 Instituições de longa permanência para idosos. Foram incluídos todos os idosos a partir de 60 anos que fossem capazes de deambular e que apresentassem bom nível cognitivo. Foram coletadas as medicações de uso contínuo e dados referentes à Instituição. Ao idoso, foi questionado se apresentou tontura no último ano. Para análise estatística, utilizou-se os testes do Qui-quadrado e Exato de Fisher para análise bivariada e regressão logística para análise múltipla stepwise forward, com nível de significância de 5%.
Resultados: dos 92 idosos avaliados, 35 afirmaram terem apresentado tontura nos últimos 12 meses (23,8%). Foram associados à tontura os antiepilépticos (p=0,034, RR= 2,26, IC95% 1,06-4,78), anti-trombóticos (p=0,008, RR= 0,21, IC95% 0,07-0,67) e diuréticos (p=0,024, RR= 2,29, IC95% 1,11-4,70), ajustados pelos psicolépticos.
Conclusão: a tontura nos idosos institucionalizados esteve associada ao uso crônico de anti-epilépticos e diuréticos.
Palavras-chave
References
1. Lo AX, Harada CN. Geriatric dizziness. Evolving diagnostic and therapeutic approaches for the emergency department. Clin Geriatr Med. 2013;29(1):181-204.
2. Shoair OA, Nyandege AN, Slattum PW. Medication-related dizziness in the older adult. Otolaryngol Clin North Am. 2011;44(2):455-71.
3. Gomez F, Curcio CL, Duque G. Dizziness as a geriatric condition among rural community-dwelling older adults. J Nutr Health Aging. 2011;15(6):490-7.
4. Kutz Junior JW. The dizzypatient. MedClin North Am. 2010;94(5):989-1002.
5. Wieshmann UC, Baker G. Efficacy and tolerability of anti-epileptic drugs-an internet study. Acta Neurol Scand. 2017;135(5):533-9. doi: 10.1111/ane.12698.
6. Helfer B, Samara MT, Huhn M, Klupp E, Leucht C, Zhu Y et al. Efficacy and Safety of Antidepressants Added to Antipsychotics for Schizophrenia: A Systematic Review and Meta-Analysis. Am J Psychiatry. 2016;173(9):876-86. doi: 10.1176/appi.ajp.2016.15081035.
7. Dalakishvili S, Bakuradze N, Gugunishvili M, Djodjua R, Areshidze E. Treatment characteristics in elderly. Georgian Med News. 2010;(187):48-51.
8. Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc.1975;23:433-41.
9. World Organization Health (WHO) Collaborating Centre for Drug Statistics Methodology. (2012). Guidelines for ATC classification and DDD assignment 2013. 16th ed. Oslo.
10. Shi S, Morike K, Klotz U. The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol. 2008;64(2):183-99
11. Cianfrone G, Petangelo D, Cianfrone F, Mazzei F, Turchetta R, Orlando MP et al. Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide. Eur Rev Med Pharmacol Sci. 2011;15(6):601-36.
12. Rochon PA, Schmader KE, Sokol NH. (Ed.). Drug prescribing for older people. Uptodate 2014. Acesso em 24 de abril de 2017. Disponível em <http://www.uptodate.com/contents/drug-prescribing-for-older-adults?source=search_result&search=medicamentos+idosos&selectedTitle=3~150>
13. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56(2):163-84.
14. Tan JL, Eastment JG, Poudel A, Hubbard RE. Age related changes in hepatic Function: an update on implications for drug therapy. Drugs Aging. 2015;32(12):999-1088.
15. Chawla N, Olshaker JS. Diagnosis and management of dizziness and vertigo. Med Clin North Am. 2006;90(2):291-304.
16. Chimirri S, Aiello R, Mazzitello C, Mumoli L, Palleria C, Altomonte M et al. Vertigo/dizziness as a Drugs' adverse reaction. J Pharmacol Pharmacother. 2013;4(1):S104-9.
17. Xiaowei Xu, Li Jiang, Man Luo, Jiaoxing Li, Weidong Li, Wenli Sheng. Perfusion-weighted magnetic resonance imaging detects recurrent isolated vertigo caused by cerebral hypoperfusion. Int J Neurosci. 2015;125(6):449-55.
Submitted date:
05/04/2017
Accepted date:
06/07/2017


